MilliporeSigma

1.06573

SAFC

di-Sodium hydrogen phosphate dodecahydrate

crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP

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Synonym(s):
Sodium phosphate dibasic dodecahydrate, Sodium monohydrogen phosphate, Sodium phosphate dibasic, sec-Sodium phosphate, Disodium hydrogen phosphate dodecahydrate, Disodium phosphate, di-Sodium hydrogen phosphate dodecahydrate
Linear Formula:
Na2HPO4 · 12H2O
CAS Number:
Molecular Weight:
358.14
MDL number:
EC Index Number:
231-448-7

agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

product line

EMPROVE® ESSENTIAL

form

crystalline
solid

pH

9.0-9.3 (20 °C, 50 g/L in H2O)

solubility

218 g/L

density

1.52 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-8°C

SMILES string

O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O

InChI

1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2

InChI key

DGLRDKLJZLEJCY-UHFFFAOYSA-L

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This Item
1.065790427371650
vibrant-m

04273

Sodium phosphate dibasic dodecahydrate

Essential Grade
solubility

218 g/L

solubility

218 g/L

solubility

-

solubility

water: soluble 35.8 g/L at 20 °C

form

crystalline, solid

form

solid

form

crystals

form

crystals

density

1.52 g/cm3 at 20 °C

density

1.52 g/cm3 at 20 °C

density

-

density

-

pH

9.0-9.3 (20 °C, 50 g/L in H2O)

pH

9.0-9.3 (20 °C, 50 g/L in H2O)

pH

8.4-9.6 (20 °C, 1%)

pH

9.0-9.3 (25 °C, 50 mg/mL in H2O)

agency

BP

agency

reag. ISO, reag. Ph. Eur.

agency

meets analytical specifications of BP, meets analytical specifications of Ph. Eur.

agency

-

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

di-Sodium hydrogen phosphate dodecahydrate is typically used as a phosphate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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