MilliporeSigma

1.06757

SAFC

Methyl 4-hydroxybenzoate

EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

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Synonym(s):
Methyl 4-hydroxybenzoate, Methylparaben, 4-Hydroxybenzoic acid methyl ester
Linear Formula:
4-(OH)C6H4(COOCH3)
CAS Number:
Molecular Weight:
152.15
MDL number:
EC Index Number:
202-785-7

Agency

BP
JP
NF
Ph. Eur.

Quality Level

vapor pressure

0.000005 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

99.0-100.5% (HPLC)
99.0-102.0% (acidimetric)

form

solid

autoignition temp.

>600 °C

technique(s)

API processing | cocrystal formation: suitable

pH

5.8 (20 °C in H2O, saturated solution)

mp

125 °C

solubility

1.88 g/L

density

1.38 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

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1 of 4

This Item
1.074271.018061.00989
Methyl 4-hydroxybenzoate EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

SAFC

1.06757

Methyl 4-hydroxybenzoate

Propyl 4-hydroxybenzoate EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

SAFC

1.07427

Propyl 4-hydroxybenzoate

Benzyl benzoate EMPROVE® EXPERT, Ph. Eur., BP, USP

SAFC

1.01806

Benzyl benzoate

Cetyl alcohol EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

SAFC

1.00989

Cetyl alcohol

form

solid

form

solid

form

liquid

form

solid

technique(s)

API processing | cocrystal formation: suitable

technique(s)

API processing | cocrystal formation: suitable

technique(s)

-

technique(s)

-

solubility

1.88 g/L

solubility

0.4 g/L

solubility

-

solubility

<0.0001 g/L

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

15-25°C

storage temp.

2-30°C

Quality Level

500

Quality Level

500

Quality Level

500

Quality Level

500

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Environment

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

334.4 °F

Flash Point(C)

168 °C


Certificates of Analysis (COA)

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705578-5MG-PW

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