1.08219

SAFC

Tris(hydroxymethyl)aminomethane hydrochloride

EMPROVE® EXPERT

Synonym(s):
TRIS HCl, Tris(hydroxymethyl)aminomethane hydrochloride, Trizma hydrochloride, TRIS hydrochloride, Tromethane hydrochloride
Linear Formula:
NH2C(CH2OH)3 · HCl
CAS Number:
Molecular Weight:
157.60
Beilstein/REAXYS Number:
3675235
MDL number:
EC Index Number:
214-684-5

storage conditions

Store at +15°C to +25°C.

Quality Level

vapor pressure

<1 Pa ( 50 °C)

product line

EMPROVE® Expert

pH

4.2 (20 °C, 100 g/L in H2O)

useful pH range

7.0 - 9.0

pKa (25 °C)

8.1

mp

150.7 °C

solubility

soluble 561 g/L

density

1.28 g/cm3 at 20.2 °C

storage temp.

15-25°C

SMILES string

Cl.NC(CO)(CO)CO

InChI

1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H

InChI key

QKNYBSVHEMOAJP-UHFFFAOYSA-N

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General description

Finding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

The pH values of all buffers are temperature and concentration dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.
For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Other Notes

Due to its low microbial and endotoxin limits, Tris(hydroxymethyl)aminomethane hydrochloride Emprove® Expert is suitable for biopharma manufacturing needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Trizma is a registered trademark of Sigma-Aldrich Co. LLC

Certificate of Analysis

Certificate of Origin

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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