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Tris(hydroxymethyl)aminomethane

GR for analysis buffer substance ACS,Reag. Ph Eur

Synonym(s):
2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol
Linear Formula:
NH2C(CH2OH)3
CAS Number:
Molecular Weight:
121.14
Beilstein:
741883
MDL number:
EC Index Number:
201-064-4

grade

ACS reagent

Quality Level

Agency

reag. Ph. Eur.

vapor pressure

0.0267 hPa ( 20 °C)

form

solid

potency

>5000 mg/kg LD50, oral (Rat)
>5000 mg/kg LD50, skin (Rat)

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

mp

167-172 °C (lit.)

solubility

678 g/L

density

1.35 g/cm3 at 23 °C

bulk density

840 kg/m3

storage temp.

15-25°C

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

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1 of 4

This Item
6483111.0838793350
Tris Base, ULTROL® Grade Useful in the pH range of 7.0-9.0. Has a pKa of 8.1 at 25°C. Absorbance (1.0 M, H2O, 260 nm):0.05.

Millipore

648311

Tris Base, ULTROL® Grade

Trizma® base puriss. p.a., ≥99.7% (T)

Sigma-Aldrich

93350

Trizma® base

agency

reag. Ph. Eur.

agency

-

agency

-

agency

-

form

solid

form

crystalline solid

form

solid

form

crystalline

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

-

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

10.5-11.5 (25 °C, 10% in H2O)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.), 168-172 °C

solubility

678 g/L

solubility

water: 1 M

solubility

678 g/L

solubility

water: soluble (678 g/l at 20 °C)

General description

Biological buffer substance
Tris is widely used as a biological buffer substance in the pH range of 7-9. For example it is used for the freezing of proteins. The grade conforms precisely with the Reag. Ph. Eur. requirements.
GR for analysis buffer substance ACS,Reag. Ph Eur

Application

Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag. Ph Eur. CAS 77-86-1, EC 201-064-4, chemical formula H₂NC(CH₂OH)₃.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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