A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
50 mg in Glass bottle
100 mg in Plastic ampoule
5, 10, 25 mg in Plastic ampoule
Product does not compete with ATP.
trypsin- and cysteine-like proteases
Cell permeable: no
Toxicity: Standard Handling (A)
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany