MilliporeSigma
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1.11609

Sigma-Aldrich

Histosec pastilles

solidification point 56-58°C embedding agent for histology

Synonym(s):
Embedding agents for microscopy, Embedding agent, Histosec

Quality Level

form

solid

potency

>3000 mg/kg LD50, skin (Rabbit)

transition temp

flash point >100 °C

bulk density

400 kg/m3

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

15-25°C

General description

Histosec pastilles - solidification point 56-58 °C embedding agent for histology, is an embedding medium for histology of samples of human origin. it is a paraffin enriched with polymers and containing DMSO (dimethyl sulfoxide). Histosec pastilles (without DMSO) (Product number 1.15161) is also available. DMSO (dimethyl sulfoxide) increases the rate of penetration of paraffin and provides additional preservation of the tissue structures. Its melting range is between 56 - 58 °C and, within this range any specimen can be processed without fear of damage irrespective of the method used. In most clinical laboratories the paraffinization is performed with an automated embedding system and is performed directly after the histoprocessing. The Histosec pastilles are well soluble with the Intermedia Xylene (isometic mixture) (Cat .no. 108298) or xylene substitutes such as Neo-Clear(Product number 1.09843).The paraffin is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

Analysis Note

Solidification point (rotating thermometer method): 56 - 58 °C
Effect of heating (at 60 °C/100 g): clear melt within max. 20 hours
Solubility in xylene (at 20 °C/0.1 g in 5 ml): clear solute within max. 20 hours
Cutting results (4 µm slices): conforms
Solubility of slices in xylene: <50 seconds

Legal Information

HISTOSEC is a trademark of Merck KGaA, Darmstadt, Germany
NEO-CLEAR is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

212.0 °F

Flash Point(C)

> 100 °C

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