1.11609

Sigma-Aldrich

Histosec pastilles

solidification point 56-58°C embedding agent for histology

Synonym(s):
Embedding agents for microscopy, Embedding agent, Histosec

storage conditions

Store at +15°C to +25°C.

Quality Level

potency

>3000 mg/kg LD50, skin (Rabbit)

application(s)

hematology: suitable
histology: suitable

transition temp

flash point >100 °C

bulk density

400 kg/m3

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

15-25°C

General description

Histosec pastilles is an embedding medium for histology of samples of human origin. It is a paraffin enriched with polymers, also available without the addition of DMSO (dimethyl sulfoxide). DMSO increases the rate of penetration of paraffin and provides additional preservation of the tissue structures. Its melting range is between 56 - 58 °C and, within this range any specimen can be processed without fear of damage irrespective of the method used.
In most clinical laboratories the paraffinization is performed with an automated embedding system and is performed directly after the histoprocessing.
The Histosec pastilles are well soluble with the Intermedia Xylene or xylene substitutes (such as Neo-Clear(R)).
The paraffin is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes.

Analysis Note

Solidification point (rotating thermometer method): 56 - 58 °C
Effect of heating (at 60 °C/100 g): clear melt within max. 20 hours
Solubility in xylene (at 20 °C/0.1 g in 5 ml): clear solute within max. 20 hours
Cutting results (4 µm slices): conforms
Solubility of slices in xylene: <50 seconds

Legal Information

HISTOSEC is a trademark of Merck KGaA, Darmstadt, Germany

Certificate of Analysis

Certificate of Origin

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