MilliporeSigma

1.20079

Millipore

Eshmuno® Q Resin

Eshmuno® Q

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Synonym(s):
Eshmuno® Q

Quality Level

ligand

(Trimethylammoniumethyl)

sterility

sterile (Caustic Stable)

product line

Eshmuno®

form

resin

specific analyte(s)

MAbs

parameter

1000 cm/hr flow rate
1000 cm/hr max. flow rate
8 bar max. pressure

matrix active group

polymer, polyvinyl ether

mean particle size

85 μm

capacity

150 mg binding capacity (BSA/mg of resin)
~150 mg, BSA binding capacity

transition temp

flash point 35 °C (own results)

density

1 g/cm3 at 20 °C

application(s)

recombinant protein
vaccine development

separation technique

anion exchange
mixed mode

storage temp.

2-30°C

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1.200891.200931.20087
vibrant-m

1.20079

Eshmuno® Q Resin

vibrant-m

1.20089

Eshmuno® A Resin

vibrant-m

1.20093

Eshmuno® CP-FT Resin

vibrant-m

1.20087

Eshmuno® HCX Resin

matrix active group

polymer, polyvinyl ether

matrix active group

polymer, polyvinyl ether

matrix active group

polymer, polyvinyl ether

matrix active group

polymer, polyvinyl ether

separation technique

anion exchange, mixed mode

separation technique

affinity

separation technique

cation exchange, strong cation exchange

separation technique

mixed mode

capacity

150 mg binding capacity (BSA/mg of resin), ~150 mg, BSA binding capacity

capacity

40-55 mg/mL binding capacity

capacity

70 mg binding capacity (lysozyme/ml of resin)

capacity

50 mg binding capacity (pIgG/ml of resin)

form

resin

form

resin

form

resin

form

resin

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-30°C

General description

Eshmuno® Q resin is a strong anion exchange resin, coupling our renowned tentacle structure with a hydrophilic polyvinyl ether base matrix. Consequently, Eshmuno® Q resin offers outstanding results in typical anion exchange applications, such as removing biomolecules′ impurities in flow-through mode.

Features and Benefits

Eshmuno® Q chromatography resin enables:

  • Purification of acidic and neutral proteins and peptides from different sources, including plasma

Superior productivity for downstream processing of biomolecules
  • High flow rate versus pressure-flow behavior
  • Excellent removal of impurities, such as HCP, leached Protein A, and viruses
  • Robust and safe packing procedures
  • Strong chemical stability

Packaging

  • 1.20079.0100: Eshmuno® Q Resin 100ml
  • 1.20079.0010: Eshmuno® Q Resin 10ml
  • 1.20079.0500: Eshmuno® Q Resin 500ml
  • 1.20079.5000: Eshmuno® Q Resin 5L

Plastic bottle

Analysis Note

Appearance: Milky cream coloured turbid suspension, free from coarse mechanical impurities.
Microscopic evaluation: Spherical particles, no agglomerates, no fines.
Extractable matter (water): ≤ 0.08 %
Ionic capacity: 90 - 190 µeq/ml
Performance test (conalbumin): 9 - 19 mS/cm
Performance test (human serum albumin): 20 - 30 mS/cm
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Protein binding capacity(bovine serum albumin): 120 - 190 mg/ml
Particle size (50-120 µm): ≥ 80 %
Particle size (d50): 75 - 95 µm
Cerium: ≤ 30 µg/g
Endotoxins: ≤ 1.00 EU/ml
TAMC (total aerobic microbial count): ≤ 100 CFU/ml
TYMC (total yeast and mould count): ≤ 100 CFU/ml

Legal Information

Eshmuno is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Flame

signalword

Warning

hcodes

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

95.0 °F

flash_point_c

35 °C


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Articles

See case study examples of how to optimize chromatographic purification of plasmid DNA for Biopharmaceutical Applications.

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A custom-designed cost model is used to explore the economics of vaccine manufacturing across several different modalities including mRNA. The model enables greater process understanding, simulates bottlenecks, and helps to optimize production efficiency.

Learn more one the attenuated viral vaccines manufacturing process: cell culture, clarification, nuclease treatment, chromatography, and sterile filtration.

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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