124012

Akt Inhibitor V, Triciribine

• Synonym(s): InSolution Akt Inhibitor V, Triciribine
• Empirical Formula (Hill Notation): C₁₃H₁₆N₆O₄
• CAS Number: 35943-35-2
• Molecular Weight: 320.30
• MDL number: MFCD00932413
• UNSPSC Code: 12352200
• NACRES: NA.28

Properties

• description: RTECS - RY8455000
• Quality Level: 100
• form: solid
• solubility: soluble (DMSO (10 mg/ml). Further dilute at aqueous buffer in low micromolar concentrations.)
• storage temp.: 2-8°C
• SMILES string: [n]2(c3ncnc4c3c(c2)C(=NN4C)N)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
• InChI: 1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
• InChI key: HOGVTUZUJGHKPL-HTVVRFAVSA-N

Description

General description

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution format (Cat. No. 124038.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable