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12-439

Retinoblastoma Protein (aa 773-928)

Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.

Synonym(s):

Rb Protein, Retinoblastoma Protein

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500 μG

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41

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recombinant

expressed in E. coli

Quality Level

100

form

liquid

manufacturer/tradename

Upstate®

concentration

2.0 mg/mL

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_000321.2

UniProt accession no.

P06400

shipped in

dry ice

Gene Information

human ... RB1(5925)

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This Item
SRP2081GF14214-520-M
Retinoblastoma Protein (aa 773-928) Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.

Sigma-Aldrich

12-439

Retinoblastoma Protein (aa 773-928)

Retinoblastoma protein human recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Sigma-Aldrich

SRP2081

Retinoblastoma protein human

Platelet Derived Growth Factor-AA Protein, Recombinant human The Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle & connective tissue.

Sigma-Aldrich

GF142

Platelet Derived Growth Factor-AA Protein, Recombinant human

Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.

Sigma-Aldrich

14-520-M

Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg

recombinant

expressed in E. coli

recombinant

expressed in insect cells

recombinant

-

recombinant

expressed in E. coli

technique(s)

activity assay: suitable (kinase)

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

activity assay: suitable (kinase)

concentration

2.0 mg/mL

concentration

400 μg/mL

concentration

-

concentration

-

form

liquid

form

frozen liquid

form

-

form

-

UniProt accession no.

P06400

UniProt accession no.

P06400

UniProt accession no.

P04085

UniProt accession no.

P48730

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

-

Physical form

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, and 500 mM imidazole

Preparation Note

Stable for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing.

Analysis Note

Routinely evaluated as a sustrate for many Serine/Threonine kinases.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Huikun Zhang et al.
PLoS computational biology, 15(8), e1006813-e1006813 (2019-08-06)
Prediction of compounds that are active against a desired biological target is a common step in drug discovery efforts. Virtual screening methods seek some active-enriched fraction of a library for experimental testing. Where data are too scarce to train supervised
Alberto Viera et al.
Journal of cell science, 128(1), 88-99 (2014-11-09)
In most organisms, telomeres attach to the nuclear envelope at the onset of meiosis to promote the crucial processes of pairing, recombination and synapsis during prophase I. This attachment of meiotic telomeres is mediated by the specific distribution of several
Petra Mikolcevic et al.
Nature communications, 7, 11084-11084 (2016-03-31)
Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) mice sterile. Here we show that mice deficient in RingoA, an atypical
Severine Isabelle Gharbi et al.
NPJ breast cancer, 8(1), 126-126 (2022-11-30)
Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood. Of particular interest, phosphorylation of CDK4 at T172 (pT172) is critical
Angie C Umaña et al.
ACS chemical biology, 13(1), 189-199 (2017-12-08)
Viral cyclin-dependent kinases (v-Cdks) functionally emulate their cellular Cdk counterparts. Such viral mimicry is an established phenomenon that we extend here through chemical genetics. Kinases contain gatekeeper residues that limit the size of molecules that can be accommodated within the
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