1.37028

Glycerol

anhydrous (vegetable), EMPROVE^® EXPERT, Ph. Eur., BP, JP, USP, ACS

• Synonym(s): 1,2,3-Propanetriol, Trihydroxylpropane, Protol, Glycerin, 1,2,3-Propanetriol, Glycerin
• Linear Formula: HOCH₂CH(OH)CH₂OH
• CAS Number: 56-81-5
• Molecular Weight: 92.09
• Beilstein: 635685
• MDL number: MFCD00004722
• EC Index Number: 200-289-5

Properties

• grade: ACS reagent
• Quality Level: 500
• Agency: BP; JP; Ph. Eur.; USP
• vapor density: 3.1 (vs air)
• vapor pressure: <1 mmHg ( 20 °C)
• product line: EMPROVE^® EXPERT
• Assay: ≤98.0-101.0% (calculated on anhydrous substance, alkalimetric); ≥99.5% (calculated on anhydrous substance, GC)
• form: liquid
• autoignition temp.: 698 °F
• expl. lim.: 2.6-11.3 % (v/v)
• technique(s): electrophoresis: suitable
• refractive index: n20/D 1.474 (lit.)
• pH: 5 (20 °C, 100 g/L in H₂O)
• bp: 182 °C/20 mmHg (lit.)
• mp: 20 °C (lit.)
• transition temp: flash point 199 °C
• density: 1.25 g/mL (lit.)
• application(s): liquid formulation; ophthalmics; parenterals; pharma/biopharma processes; pharmaceutical
• storage temp.: 2-30°C
• SMILES string: OCC(O)CO
• InChI: 1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
• InChI key: PEDCQBHIVMGVHV-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Glycerol can be used in a wide variety of solid, semi-solid and liquid formulations, including ophthalmic, oral solid and oral liquid dosages, tablet coatings, creams and gels. It is applied for its humectant, emollient, solvent/cosolvent, viscosity increasing, and plasticizer properties.
Glycerol anhydrous (vegetable) Emprove^® Expert is low in endotoxins and bioburden, making it the right choice for your high-risk applications.

Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel′s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 390.2 °F - Pensky-Martens closed cup
• Flash Point(C): 199 °C - Pensky-Martens closed cup