1.37112

Poloxamer 188

EMPROVE^® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., NF

• Synonym(s): Polyethylene glycol, propoxylated
• Linear Formula: (C₃H₆O · C₂H₄O)_x
• CAS Number: 9003-11-6
• MDL number: MFCD00082049

Properties

• Agency: NF; Ph. Eur.
• Quality Level: 500
• product line: EMPROVE^® EXPERT
• form: solid
• technique(s): API processing | nano-milling: suitable
• pH: 5-7.5 (20 °C, 10 g/L in H₂O)
• mp: 52 °C
• transition temp: flash point 260 °C
• density: 1.06 g/cm³ at 70 °C
• application(s): biopharma process and formulation; liquid formulation; ophthalmics; parenterals; pharmaceutical; semi-solid formulation; solid formulation; solubility enhancement
• storage temp.: 2-25°C
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Poloxamer 188 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.
Due to its low microbial and endotoxin limits, Poloxamer 188 Emprove^® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable