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165350

Sigma-Aldrich

PARP Inhibitor I, 3-ABA

The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

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Synonym(s):
PARP Inhibitor I, 3-ABA, 3-Aminobenzamide
Empirical Formula (Hill Notation):
C7H8N2O
CAS Number:
Molecular Weight:
136.15
MDL number:

Quality Level

assay

≥99% (GC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

ethanol: 1 mg/mL
water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)

InChI key

GSCPDZHWVNUUFI-UHFFFAOYSA-N

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PARP Inhibitor I, 3-ABA

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manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

form

solid

form

solid

form

solid

form

solid

assay

≥99% (GC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

color

light brown

color

off-white

color

white

General description

A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PARP
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.

Other Notes

Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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