165350

PARP Inhibitor I, 3-ABA

The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): PARP Inhibitor I, 3-ABA, 3-Aminobenzamide
• Empirical Formula (Hill Notation): C₇H₈N₂O
• CAS Number: 3544-24-9
• Molecular Weight: 136.15
• MDL number: MFCD00007989
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• description: RTECS - CU8992000
• Quality Level: 100
• assay: ≥99% (GC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: ethanol: 1 mg/mL; water: 1 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: Nc1cc(ccc1)C(=O)N
• InChI: 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
• InChI key: GSCPDZHWVNUUFI-UHFFFAOYSA-N

Description

General description

A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PARP

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.

Other Notes

Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3