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Amyloid Precursor Protein β-Secretase Inhibitor

The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

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Synonym(s):
Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF
Empirical Formula (Hill Notation):
C73H118N16O27
Molecular Weight:
1651.81

Quality Level

assay

≥98% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

aqueous buffer, pH 7.5: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC50 = 30 nM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
APP
Product does not compete with ATP.
Reversible: no
Target IC50: 30 nM against amyloid precursor protein (APP) β-secretase

Warning

Toxicity: Standard Handling (A)

Sequence

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sinha, S., et al. 1999. Nature 402, 537.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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