The optimal working concentration of the product is cell type and application dependent. Typically, a working concentration in the range of 0.5 to 2 uM is recommended.
189825
5-Aza-2′-Deoxycytidine
A cytosine analog that acts as a DNA methyltransferase inhibitor.
Synonym(s):
5-Aza-2′-Deoxycytidine, 5-Aza-CdR, 5-Aza-dC, 2′-Deoxy-5-azacytidine, Decitabine
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Check Cart for Availability | $386.00 |
About This Item
Empirical Formula (Hill Notation):
C8H12N4O4
CAS Number:
Molecular Weight:
228.21
UNSPSC Code:
12352208
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
lyophilized
Storage condition:
OK to freeze
$386.00
Check Cart for Availability
Quality Segment
description
RTECS - XZ3012000
assay
≥98% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
methanol: 1 mg/mL, 50% acetic acid: 25 mg/mL, DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO
InChI
1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI key
XAUDJQYHKZQPEU-UHFFFAOYSA-N
General description
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. Also available as a 100 mM solution in DMSO (Cat. No. 189826).
Biochem/physiol Actions
Primary Target
DNA methyltransferase inhibitor
DNA methyltransferase inhibitor
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
warming is required to achieve complete solubilization
Other Notes
Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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This Item | |||
|---|---|---|---|
| description A cytosine analog that acts as a DNA methyltransferase inhibitor. | description InSolution, ≥98%, DNA methyltransferase inhibitor | description ≥97% | description United States Pharmacopeia (USP) Reference Standard |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% | assay - |
| form lyophilized | form liquid | form powder | form - |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename USP |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. - | storage temp. 2-8°C |
| solubility methanol: 1 mg/mL, 50% acetic acid: 25 mg/mL, DMSO: 25 mg/mL | solubility - | solubility acetic acid: water (1:1): 50 mg/mL | solubility - |
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signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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Please provide a brief idea of how much 5-Aza-2ʹ-Deoxycytidine must be added to cell culture to yield the best results with product number 189825-25MG?
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