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19-123-M

Sigma-Aldrich

Staurosporine

Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.

Synonym(s):

PKC inhibitor, protein kinase C inhibitor

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200 μG
$344.00
1 MG
$729.00

$344.00


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200 μG
$344.00
1 MG
$729.00

About This Item

UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41

$344.00


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Quality Level

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

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37095S5921S4400
Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

300

manufacturer/tradename

Upstate®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

technique(s)

activity assay: suitable (kinase)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

General description

Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.

Application

Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.[1]

Biochem/physiol Actions

Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.

Quality

Routinely evaluated by Protein Kinase Inhibition Assay

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Health hazard

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Questions

  1. What is the buffer for Staurosporine rework? At what concentration should it be resumed? Storage in aliquots at what temperature and for how long. Thank you

    1 answer
    1. Staurosporine is soluble in ethyl acetate, DMSO at 5 mg/mL, and DMF. It is slightly soluble in chloroform and methanol at 2 mg/mL, and insoluble in water. Stock solutions should be aliquoted, purged with an inert gas, and stored at -20 °C, where they should remain stable for approximately 6 months.

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