Staurosporine is soluble in ethyl acetate, DMSO at 5 mg/mL, and DMF. It is slightly soluble in chloroform and methanol at 2 mg/mL, and insoluble in water. Stock solutions should be aliquoted, purged with an inert gas, and stored at -20 °C, where they should remain stable for approximately 6 months.
19-123-M
Staurosporine
Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.
Synonym(s):
PKC inhibitor, protein kinase C inhibitor
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200 μG
$344.00
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200 μG
$344.00
1 MG
$729.00
About This Item
UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41
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$344.00
-15% with code SMR15
Web-Only Discount
Check Cart for Availability
Related Categories
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This Item | 37095 | S5921 | S4400 |
|---|---|---|---|
| Quality Level 100 | Quality Level 100 | Quality Level 300 | Quality Level 300 |
| manufacturer/tradename Upstate® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename - |
| technique(s) activity assay: suitable (kinase) | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
General description
Suitable for use as a potent inhibitor of PKC and other protein kinases in vitro and in cultured cells.
Application
Staurosporine has been used as a protein kinase inhibitor to study the ubiquitin-protein ligase E3 component N-recognin 5 (UBR5)-mediated CDC73 regulation at the protein level. Staurosporine has been used to induce apoptosis in CHO-K1 cell lines, followed by cell imaging and extraction of cell lysate for further analysis.[1]
Biochem/physiol Actions
Staurosporine, a broad-spectrum protein kinase inhibitor, belongs to the indolocarbazole family. It is referred to as a prototypical ATP-competitive kinase inhibitor. Staurosporine is effective against various kinds of cancers. It is commonly used for inducing apoptosis in different types of cells.
Quality
Routinely evaluated by Protein Kinase Inhibition Assay
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Repr. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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What is the buffer for Staurosporine rework? At what concentration should it be resumed? Storage in aliquots at what temperature and for how long. Thank you
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