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197900

Sigma-Aldrich

BEC, Hydrochloride

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).

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Synonym(s):
BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)
Empirical Formula (Hill Notation):
C5H12BNO4S · xHCl
Molecular Weight:
193.03 (free base basis)

Quality Level

Assay

≥97% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
362339AB5382SML1384
BEC, Hydrochloride A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).

Sigma-Aldrich

197900

BEC, Hydrochloride

Glyco-SNAP-2 A water-soluble nitric oxide (NO) donor that exhibits greater stability (t1/2 = 27 hours) than that of SNAP.

Sigma-Aldrich

362339

Glyco-SNAP-2

BEC hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1384

BEC hydrochloride

form

solid

form

solid

form

-

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Chemicon®

manufacturer/tradename

-

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

desiccated

color

white

color

green

color

-

color

white to beige

solubility

water: 10 mg/mL

solubility

aqueous buffer: >100 mg/mL, methanol: soluble, water: soluble

solubility

-

solubility

H2O: 20 mg/mL, clear

General description

A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.

Biochem/physiol Actions

Cell permeable: no
Primary Target
arginase 1, arginase 2
Product does not compete with ATP.
Reversible: no
Target Ki: 310 nM for human recombinant type II arginase, pH 7.5

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.

Other Notes

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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