200487

Sigma-Aldrich

β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem

The β-Amyloid Oligomer Inhibitor, K01-162 controls the biological activity of β-Amyloid Oligomer.

Synonym(s):
AβO Inhibitor, K01-162, β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem
Empirical Formula (Hill Notation):
C15H14BrN
Molecular Weight:
288.18
Pricing and availability is not currently available.

storage conditions

+2C to +8C

Quality Level

assay

≥95% (HPLC)

form

solid

mfr. no.

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

color

white to off-white

solubility

DMSO: 50 mg/mL

shipped in

ambient

General description

A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.

Packaging

10 mg in Glass bottle
Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Hong, H-S., et al. 2010. Neurobiol. Aging31, 1690.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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