Skip to Content
MilliporeSigma

203291

Sigma-Aldrich

Bisindolylmaleimide I, Hydrochloride

An enhanced water-soluble form of Bisindolylmaleimide I.

Synonym(s):

Bisindolylmaleimide I, Hydrochloride, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl

Slide 1 of 1
Sign Into View Organizational & Contract Pricing

Select a Size

1 MG
$175.00

$175.00

Check Cart for Availability

About This Item

Empirical Formula (Hill Notation):
C25H24N4O2 · xHCl
CAS Number:
176504-36-2
Molecular Weight:
412.48 (free base basis)
MDL number:
MFCD00236429
UNSPSC Code:
12352111
NACRES:
NA.77

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

orange-red

solubility

water: 10 mg/mL
DMSO: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Cl.N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)cccc3

InChI

1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H

InChI key

XRAMWNCMYJHGGH-UHFFFAOYSA-N

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
203290203293574711
Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I.

Sigma-Aldrich

203291

Bisindolylmaleimide I, Hydrochloride

Bisindolylmaleimide I A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine.

Sigma-Aldrich

203290

Bisindolylmaleimide I

Bisindolylmaleimide I InSolution, ≥95%, protein kinase C (PKC) inhibitor

Sigma-Aldrich

203293

Bisindolylmaleimide I

Syk Inhibitor The Spleen Tyrosine Kinase Inhibitor, also referenced under CAS 622387-85-3, controls the biological activity of Spleen Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

574711

Syk Inhibitor

form

solid

form

solid

form

liquid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (sum of two isomers, HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

General description

A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). Inhibits protein kinase A at much higher concentrations (Ki = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290 ). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Protein kinase C
Product competes with ATP.
Reversible: yes
Target Ki: 10 nM against protein kinase C

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

K J Christopher et al.
The Journal of physiology, 515 ( Pt 2), 511-522 (1999-03-02)
1. During development, embryos of the pulmonate gastropod, Helisoma trivolvis, undergo a rotation behaviour due to the co-ordinated beating of three bands of ciliated epithelial cells. This behaviour is in part mediated by the neurotransmitter serotonin (5-HT) released from a
Stephen R Reeves et al.
Experimental physiology, 92(6), 1057-1066 (2007-08-07)
Protein kinase C (PKC) is a broadly expressed and critically important signalling protein with a wide range of functional roles, including central components of respiratory control. For example, systemic and targeted administration of PKC inhibitors within the nucleus of the

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service