204910

Complement C9, Human

Complement C9, Human, CAS 80295-59-6, is a native, single-chain glycoprotein present in normal human serum at 60 µg/ml.

• Synonym(s): Complement C9, Human
• CAS Number: 80295-59-6
• UNSPSC Code: 12352202
• NACRES: NA.25
• MDL number: MFCD00130849
• Form: liquid
• Assay: ≥95% (SDS-PAGE)

Properties

• Quality Level: 200
• assay: ≥95% (SDS-PAGE)
• form: liquid
• specific activity: ≥150,000 C9H50 units/mg
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, avoid repeated freeze/thaw cycles
• impurities: IgG, IgA, IgM, albumin, C3, C4, C5, C6, C7, or C8, trace
• shipped in: wet ice
• storage temp.: −70°C

Description

General description

Native, human C9 complement component. Single-chain glycoprotein present in normal human serum at 60 µg/ml. On activation of complement via either the classical or alternative pathway, formation of the C5b fragment initiates assembly of the C5b-9 complement membrane attack complex (MAC) on target surfaces. Full lytic activity of MAC occurs only after binding of three to six C9 molecules to each C5b-8 complex.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In PBS, pH 7.2, filtered through a 0.22 µm pore size filter.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Stanley, K.K., et al. 1985. EMBO J. 4, 375.
Biesecker, G. and Muller-Eberhard, H.J. 1980. J. Immunol. 124, 1291.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable