A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
1 mg in Plastic ampoule
Cell permeable: yes
Product does not compete with ATP.
Target IC50: 2.24 nM against cathepsin B
Toxicity: Standard Handling (A)
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany