211875
Captopril
An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC₅₀ = 11 µM).
Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
Empirical Formula (Hill Notation):
C9H15NO3S
Recommended Products
Quality Level
assay
≥98% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to off-white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChI key
FAKRSMQSSFJEIM-RQJHMYQMSA-N
General description
An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).
An antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.
Biochem/physiol Actions
Cell permeable: no
Primary Target
ACE
ACE
Product does not compete with ATP.
Reversible: yes
Target IC50: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Other Notes
Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Muta. 2 - Repr. 1B
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service