218708

Sigma-Aldrich

InSolution Casein Kinase II Inhibitor I - Calbiochem

The InSolution Casein Kinase II Inhibitor I controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):
InSolution Casein Kinase II Inhibitor I - Calbiochem
Empirical Formula (Hill Notation):
C6HBr4N3
Molecular Weight:
434.71
Pricing and availability is not currently available.

storage conditions

+2C to +8C

Quality Level

form

liquid

mfr. no.

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

shipped in

wet ice

General description

A cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50<1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).

Packaging

5 mg in Plastic ampoule
Packaged under inert gas

Biochem/physiol Actions

Reversible: yes
Cell permeable: yes
Primary Target
CK2 rat liver, human recombinant
Product competes with ATP.
Target IC50: 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Physical form

A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.

Reconstitution

Following initial use, aliquot and refrigerate (4°C).

Analysis Note

Single spot by TLC

Other Notes

Borowski, P., et al. 2003. Eur. J. Biochem.270, 1645.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun.306, 129.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Sarno, S., et al. 2001. FEBS Lett.496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun.208, 418."

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 2

Flash Point(F)

188.6 °F - (Dimethylsulfoxide)

Flash Point(C)

87 °C - (Dimethylsulfoxide)

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