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  • 218728
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218728

Sigma-Aldrich

Caspase-9 Inhibitor III

The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):
Caspase-9 Inhibitor III, Ac-LEHD-CMK
Empirical Formula (Hill Notation):
C24H35ClN6O9
CAS Number:
Molecular Weight:
587.02

Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

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264155218750218745
Caspase Inhibitor III The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218745

Caspase Inhibitor III

assay

≥95% (HPLC)

assay

≥90% (TLC)

assay

≥98% (HPLC)

assay

-

form

solid

form

solid

form

lyophilized solid, powder

form

semisolid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

color

white

color

white to slightly brown

color

white to off-white

color

off-white

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL

solubility

20% acetonitrile: 1 mg/mL

solubility

DMSO: 5 mg/mL

General description

A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-9
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against caspase-9

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Leu-Glu-His-Asp-CMK

Other Notes

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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