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218735

Sigma-Aldrich

Caspase Inhibitor II

The Caspase Inhibitor II, also referenced under CAS 147837-52-3, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):
Caspase Inhibitor II, Ac-VAD-CHO
Empirical Formula (Hill Notation):
C14H23N3O6
CAS Number:
Molecular Weight:
329.35
MDL number:

Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 150 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C14H23N3O6/c1-7(2)12(16-9(4)19)14(23)15-8(3)13(22)17-10(6-18)5-11(20)21/h6-8,10,12H,5H2,1-4H3,(H,15,23)(H,16,19)(H,17,22)(H,20,21)/t8-,10-,12-/m0/s1

InChI key

BGFYQRSQECIBIB-PEXQALLHSA-N

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Caspase Inhibitor II The Caspase Inhibitor II, also referenced under CAS 147837-52-3, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218735

Caspase Inhibitor II

assay

≥95% (HPLC)

assay

≥90% (TLC)

assay

≥95% (HPLC)

assay

-

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, protect from light

color

white

color

white to slightly brown

color

white

color

white

solubility

DMSO: 150 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

General description

A potent and reversible inhibitor of caspases.
A potent and reversible pan-caspase inhibitor.

Biochem/physiol Actions

Cell permeable: no
Primary Target
pan-caspase
Product does not compete with ATP.
Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Val-Ala-Asp-CHO

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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