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218744

Sigma-Aldrich

Caspase-2 Inhibitor I

The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):
Caspase-2 Inhibitor I, Z-VD(OMe)VAD(OMe)-FMK
Empirical Formula (Hill Notation):
C32H46FN5O11
Molecular Weight:
695.73

Quality Level

assay

≥95% (HPLC)
≥95% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
400011218746218753
vibrant-m

218744

Caspase-2 Inhibitor I

vibrant-m

218746

Caspase-1 Inhibitor VI

vibrant-m

218753

Caspase-5 Inhibitor I

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

lyophilized

form

solid

form

powder

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

General description

A cell-permeable and irreversible inhibitor of caspase-2 (ICH-1)
An irreversible inhibitor of caspase-2 (ICH-1).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-2
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Zahara L Chaudhry et al.
Brain sciences, 12(4) (2022-04-22)
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in host, which may exacerbate symptoms and/or
Zahara L Chaudhry et al.
Brain sciences, 10(11) (2020-11-05)
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease (PD). Increasing evidence

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