218744

Sigma-Aldrich

Caspase-2 Inhibitor I - Calbiochem

The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):
Caspase-2 Inhibitor I - Calbiochem, Z-VD(OMe)VAD(OMe)-FMK
Empirical Formula (Hill Notation):
C32H46FN5O11
Molecular Weight:
695.73

storage conditions

-20C

Quality Level

assay

≥95% (HPLC)
≥95% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

An irreversible inhibitor of caspase-2 (ICH-1).
A cell-permeable and irreversible inhibitor of caspase-2 (ICH-1)

Packaging

1 mg in Plastic ampoule
250 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
caspase-2

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Zahara L Chaudhry et al.
Brain sciences, 10(11) (2020-11-05)
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease (PD). Increasing evidence...

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