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218750

Sigma-Aldrich

Caspase-3 Inhibitor III

The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

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Synonym(s):
Caspase-3 Inhibitor III, Ac-DEVD-CMK
Empirical Formula (Hill Notation):
C21H31ClN4O11
CAS Number:
Molecular Weight:
550.94

Quality Level

Assay

≥98% (HPLC)

form

lyophilized solid
powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to off-white

solubility

20% acetonitrile: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
264155235420218745
Caspase-3 Inhibitor I The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

235420

Caspase-3 Inhibitor I

Caspase Inhibitor III The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218745

Caspase Inhibitor III

form

lyophilized solid, powder

form

solid

form

solid

form

semisolid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

color

white to off-white

color

white to slightly brown

color

white

color

off-white

solubility

20% acetonitrile: 1 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL, water: soluble

solubility

DMSO: 5 mg/mL

General description

A potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.
A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Asp-Glu-Val-Asp-CMK

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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