A cell-permeable, irreversible inhibitor of caspase-6 (Mch-2).
A cell-permeable, irreversible inhibitor of caspase-6. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
Biochem/physiol Actions
Cell permeable: yes
Primary Target caspase-6
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH₂F*
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has been confirmed independently by ribosome profiling.
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