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Sigma-Aldrich

Caspase-6 Inhibitor I

The Caspase-6 Inhibitor I controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-6 Inhibitor I, Z-VE(OMe)ID(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C31H45FN4O10
Molecular Weight:
652.71
UNSPSC Code:
12352200

Quality Level

assay

≥90% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable, irreversible inhibitor of caspase-6 (Mch-2).
A cell-permeable, irreversible inhibitor of caspase-6. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-6
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Hazel Stewart et al.
iScience, 26(11), 108080-108080 (2023-10-20)
The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has been confirmed independently by ribosome profiling.

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