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219415

Sigma-Aldrich

Cathepsin Inhibitor I

The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin Inhibitor I, Z-FG-NHO-Bz, CATI -1

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About This Item

Empirical Formula (Hill Notation):
C26H25N3O6
Molecular Weight:
475.49
UNSPSC Code:
12352200
NACRES:
NA.77

$192.00

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Quality Level

100

assay

>90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: soluble
acetonitrile: soluble
ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

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This Item
219419219421219372
Cathepsin Inhibitor I The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

219415

Cathepsin Inhibitor I

Cathepsin Inhibitor III The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

219419

Cathepsin Inhibitor III

Cathepsin L Inhibitor I The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

219421

Cathepsin L Inhibitor I

Cathepsin G Inhibitor I The Cathepsin G Inhibitor I, also referenced under CAS 429676-93-7, controls the biological activity of Cathepsin G. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

219372

Cathepsin G Inhibitor I

assay

>90% (HPLC)

assay

>90% (HPLC)

assay

-

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

10-30°C

storage temp.

10-30°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: soluble, ethanol: soluble, acetonitrile: soluble

solubility

ethanol: 1 mg/mL, DMSO: 5 mg/mL

solubility

DMSO: 20 mM

solubility

DMSO: 5 mg/mL, methanol: soluble

General description

Cell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1 sec-1), and papain (k2/Ki = 2.4 x 103 M-1 sec-1).
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1sec-1), and papain (k2/Ki = 2.4 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Phe-Gly-NHO-Bz

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res.6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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