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219427

Sigma-Aldrich

Cathepsin L Inhibitor III - Calbiochem

The Cathepsin L Inhibitor III controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):
Cathepsin L Inhibitor III - Calbiochem, Z-FY(t-Bu)-DMK, Z-FY( t-Bu)-DMK
Empirical Formula (Hill Notation):
C31H34N4O5
Molecular Weight:
542.63

Quality Level

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to light yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

An irreversible inhibitor of Cathepsin L (Cat. No. 219402). About 10,000-fold more effective against cathepsin L than cathepsin S.
An irreversible inhibitor of Cathepsin L (Cat. No. 219402). About 10,000-fold more effective against cathepsin L than cathepsin S.

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Cathepsin L
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Phe-Tyr(t-Bu)-diazomethylketone

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Other Notes

Shaw, E., et al. 1993. FEBS Lett. 334, 340.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Quality

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Xiaoxun Li et al.
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Background: Bone metastasis is a frequent symptom of breast cancer and current targeted therapy has limited efficacy. Osteoclasts play critical roles to drive osteolysis and metastatic outgrowth of tumor cells in bone. Previously we identified CST6 as a secretory protein
Cong Zeng et al.
bioRxiv : the preprint server for biology (2021-06-09)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus responsible for the global COVID-19 pandemic. Herein we provide evidence that SARS-CoV-2 spreads through cell-cell contact in cultures, mediated by the spike glycoprotein. SARS-CoV-2 spike is more efficient
Swetha Mohan et al.
Molecular neurodegeneration, 16(1), 51-51 (2021-08-05)
Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are increasingly thought to contribute to FTLD-TDP-Pgrn disease pathophysiology.

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