219433

Cathepsin L Inhibitor IV

The Cathepsin L Inhibitor IV controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): Cathepsin L Inhibitor IV, 1-Naphthalenesulfonyl-IW-CHO
• Empirical Formula (Hill Notation): C₂₇H₂₉N₃O₄S
• Molecular Weight: 491.60

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 1.9 nM against Cathepsin L

Warning

Toxicity: Standard Handling (A)

Sequence

1-Naphthalenesulfonyl-Ile-Trp-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable