219672

CFTR Inhibitor III, OXO-172

The CFTR Inhibitor III, OXO-172 controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Synonym(s): CFTR Inhibitor III, OXO-172, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172
• Empirical Formula (Hill Notation): C₁₈H₁₀F₃NO₄S
• Molecular Weight: 393.34
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC, NMR)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: ethanol: 1 mg/mL; DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable CFTR_inh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR_inh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR_inh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC₅₀ = 1.4 µM vs. 0.38 µM with CFTR_inh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem.16, 8187.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable