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220467

Sigma-Aldrich

2-Chloro-2′-deoxyadenosine

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

Synonym(s):
2-Chloro-2′-deoxyadenosine, 2CdA, Cladribine
Empirical Formula (Hill Notation):
C10H12ClN5O3
CAS Number:
Molecular Weight:
285.69
MDL number:

Quality Level

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChI key

PTOAARAWEBMLNO-KVQBGUIXSA-N

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This Item
1134200Y0000639Y0000609
Cladribine United States Pharmacopeia (USP) Reference Standard

USP

1134200

Cladribine

Cladribine European Pharmacopoeia (EP) Reference Standard

Y0000639

Cladribine

assay

≥95% (HPLC)

assay

-

assay

-

assay

-

form

solid

form

-

form

-

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

color

white

color

-

color

-

color

-

solubility

DMSO: 5 mg/mL

solubility

-

solubility

-

solubility

-

General description

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Antileukemic and immunosuppressive activity
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Other Notes

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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