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227016

CCR2 Antagonist

≥97% (racemic mixture, HPLC), solid, CCR2 antagonist, Calbiochem®

Synonym(s):

CCR2 Antagonist, 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist

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5 MG

$270.00

$270.00

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About This Item

Empirical Formula (Hill Notation):
C28H34F3N5O4S
CAS Number:
445479-97-0
Molecular Weight:
593.66
MDL number:
MFCD00133899
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

CCR2 Antagonist, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

assay

≥97% (racemic mixture, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

ethanol: 6 mg/mL
DMSO: 60 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

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CCR2 Antagonist The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Glucagon Receptor Antagonist II The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.

Sigma-Aldrich

346003

Glucagon Receptor Antagonist II

assay

≥97% (racemic mixture, HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

ethanol: 6 mg/mL, DMSO: 60 mg/mL

solubility

DMSO: 50 mg/mL, light brown

solubility

ethanol: 2 mg/mL, DMSO: 28 mg/mL

solubility

DMSO: 45 mg/mL, ethanol: 45 mg/mL

Disclaimer

Toxicity: Standard Handling (A)

General description

A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.

Other Notes

Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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