23-033-M

MDM2 (c-Myc tagged) Protein, active, 10 µg

Name: MDM2 (c-Myc tagged) Protein, active, 10 µg
Brand: MM
Price: 4450 USD

Active, full length, recombinant human MDM2. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Synonym(s):

Double minute 2 protein, p53-binding protein Mdm2, Hdm2

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250 μG

$4,450.00

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About This Item

UNSPSC Code:

12352202

eCl@ss:

32160405

NACRES:

NA.41

Key Documents

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biological source

human

Quality Level

100

recombinant

expressed in E. coli

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable

GenBank accession no.

AF527840

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This Item	23-032-M	MABE340-AF555	MABE340-AF488
Sigma-Aldrich 23-033-M MDM2 (c-Myc tagged) Protein, active, 10 µg	Sigma-Aldrich 23-032-M MDM2/CK1δ Protein, active, 10 µg	Sigma-Aldrich MABE340-AF555 Anti-MDM2 Antibody, clone IF2, Alexa Fluor^™ 555 Conjugate	Sigma-Aldrich MABE340-AF488 Anti-MDM2 Antibody, clone IF2, Alexa Fluor^™ 488 Conjugate
recombinant expressed in E. coli	recombinant -	recombinant -	recombinant -
biological source human	biological source human	biological source mouse	biological source mouse
technique(s) activity assay: suitable	technique(s) activity assay: suitable	technique(s) immunocytochemistry: suitable	technique(s) immunocytochemistry: suitable
Quality Level 100	Quality Level 300	Quality Level 100	Quality Level 100
manufacturer/tradename Upstate^®	manufacturer/tradename Upstate^®	manufacturer/tradename -	manufacturer/tradename -
GenBank accession no. AF527840	GenBank accession no. AF527840	GenBank accession no. -	GenBank accession no. -

General description

MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli.

Application

Ubiquitination Cascade Comoponent: E3

Physical form

Purified using glutathione sepharose followed by gel filtration.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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MDM2 (c-Myc tagged) Protein, active, 10 µg