235752

Sigma-Aldrich

Anti-C-Reactive Protein Rabbit pAb

liquid, Calbiochem®

Synonym(s):
Anti-CRP

storage conditions

-20C

biological source

rabbit

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

General description

Rabbit polyclonal antibody purified by DEAE anion exchange chromatography. Recognizes C-reactive protein.
Recognizes C-reactive protein. Does not exhibit cross-reactivity against normal human serum.

Immunogen

purified, human CRP

Packaging

1 ml in Glass bottle
Please refer to vial label for lot-specific concentration.

Application

ELISA (see application references)

Immunoblotting (0.1 µg/ml,see application references)

Immunoprecipitation (see comments)

Radioimmunoassay (see comments)

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 15 mM phosphate buffer, pH 7.2-7.4.

Other Notes

Exhibits a single precipitin line against CRP control serum. Does not exhibit cross-reactivity against normal human serum. The optimal dilution for RIA and immunoprecipitation should be determined for each sample type. Antibody should be titrated for optimal results in individual systems.
Ridker, P.M., et al. 1997. N. Engl. J. Med.336, 973.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

storage_class_code

10 - Combustible liquids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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Maurice Swinkels et al.
Scientific reports, 8(1), 1643-1643 (2018-01-28)
Retinal inflammation plays a key role in the progression of age-related macular degeneration (AMD), a condition that leads to loss of central vision. The deposition of the acute phase pentraxin C-reactive protein (CRP) in the macula activates the complement system...
Donald N Ngwa et al.
Frontiers in immunology, 11, 586669-586669 (2020-10-30)
C-reactive protein (CRP) binds to several species of bacterial pathogens including Streptococcus pneumoniae. Experiments in mice have revealed that one of the functions of CRP is to protect against pneumococcal infection by binding to pneumococci and activating the complement system....
Asmita Pathak et al.
Frontiers in immunology, 11, 1780-1780 (2020-08-28)
The aim of this study was to test the hypothesis that C-reactive protein (CRP) protects against the development of atherosclerosis and that a conformational alteration of wild-type CRP is necessary for CRP to do so. Atherosclerosis is an inflammatory cardiovascular...
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