There is a slight difference in the chemical structure of each compound. Cytochalasin B is a cell-permeable fungal toxin. It Inhibits cytoplasmic division by blocking the formation of contractile microfilaments, inhibits cell movement, and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast growing end of polymers. It also Inhibits glucose transport and platelet aggregation, blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly. It has an effect on cell motility and morphology similar to that of cytochalasin B. However, it does not inhibit glucose transport. The following publication may be of interest:
https://pubmed.ncbi.nlm.nih.gov/272649/
250233
Cytochalasin B
from Helminthosporium dematioideum, ≥98% (HPLC), solid, cell-permeable fungal toxin, Calbiochem®
Synonym(s):
Cytochalasin B, Helminthosporium dematioideum
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $229.00 |
About This Item
Product Name
Cytochalasin B, Helminthosporium dematioideum, Cell-permeable fungal toxin.
Quality Segment
description
Merck USA index - 14, 2790
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
methanol: 20 mg/mL, DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N1[C@H]([C@H]3[C@@]4(OC(=O)\C=C\[C@@H](CCC[C@H](C\C=C\[C@H]4[C@@H](C(=C)[C@H]3C)O)C)O)C1=O)Cc2ccccc2
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI key
GBOGMAARMMDZGR-TYHYBEHESA-N
General description
Biochem/physiol Actions
Blocking the formation of contractile microfilaments
Preparation Note
Other Notes
Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
Cairns, M.T., et al. 1991. J. Biol. Chem.266, 8176.
Nowak, D. 1990. Biomed. Biochim. Acta49, 353.
Wang, F., et al. 1990. Biochem. Biophys. Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988. FEBS Lett.227, 39.
Legal Information
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| description Cell-permeable fungal toxin. | description Induces changes in cell morphology and motility with no effect on sugar transport. | description ≥98% (HPLC), powder | description A cell-permeable DNA topoisomerase I inhibitor. |
| form solid | form solid | form powder | form solid |
| assay ≥98% (HPLC) | assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 300 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light | storage condition - | storage condition OK to freeze |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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Cytochalasin B, Helminthosporium dematioideum & other option is Dihydrocytochalasin B. What is the difference?
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