The substance dissolves in DMSO at concentrations of up to 8 mg/ml.
317240
Metformin
≥97% (titration), solid, AMPK signaling activator, Calbiochem®
Synonym(s):
Metformin, 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
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About This Item
Empirical Formula (Hill Notation):
C4H11N5 · xHCl
CAS Number:
Molecular Weight:
129.16 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Product Name
Metformin, An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
Quality Level
description
Merck USA index - 14, 5938
assay
≥97% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
Cl.N(C)(C)C(=N\C(=N\[H])\N)N
InChI
1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI key
OETHQSJEHLVLGH-UHFFFAOYSA-N
Related Categories
1 of 4
This Item | BP227 | 1396309 | M0605000 |
|---|---|---|---|
| assay ≥97% (titration) | assay - | assay - | assay - |
| form solid | form crystalline | form - | form - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| manufacturer/tradename Calbiochem® | manufacturer/tradename BP | manufacturer/tradename USP | manufacturer/tradename EDQM |
| storage temp. 10-30°C | storage temp. 2-8°C | storage temp. - | storage temp. - |
| solubility water: 50 mg/mL | solubility - | solubility - | solubility - |
General description
An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
Biochem/physiol Actions
Cell permeable: no
Primary Target
AMP-activated protein kinase (AMPK)
AMP-activated protein kinase (AMPK)
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Related Content
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What is the solubility of Metformin (Cat#317240) in DMSO?
1 answer-
Helpful?
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is metformin accociated with paracitic worms?
1 answer-
There have been studies published regarding the efficacy of Metformin against various parasites. Please see the link below to review one such study of Echinococcisis. Note that this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321462/Helpful?
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