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317700

Sigma-Aldrich

Dkk-1 Inhibitor, WAY-262611, HCl

The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

Synonym(s):

Dkk-1 Inhibitor, WAY-262611, HCl, (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

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10 MG
$207.00

$207.00

Estimated to ship onJune 16, 2025

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10 MG
$207.00

About This Item

Empirical Formula (Hill Notation):
C20H22N4 · xHCl
Molecular Weight:
318.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

$207.00

Estimated to ship onJune 16, 2025

Quality Level

100

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

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Dkk-1 Inhibitor, WAY-262611, HCl The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

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Wnt Pathway Inhibitor XI, CCT036477

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (1H-NMR)

form

powder

form

powder

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 25 mg/mL

solubility

DMSO: 10 mg/mL, hydrogen: 2.5 mg/mL

solubility

DMSO: 100 mg/mL, clear, red

solubility

DMSO: 50 mg/mL

General description

A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Pelletier, J.C., et al. 2009. J. Med. Chem.52, 6962.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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