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Sigma-Aldrich

PARP Inhibitor IX, EB-47

The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

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Synonym(s):
PARP Inhibitor IX, EB-47
Empirical Formula (Hill Notation):
C24H27N9O6 · 2HCl · 2H2O
Molecular Weight:
646.48

Quality Level

Assay

≥95% (HPLC)

form

solid

potency

45 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

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This Item
616463528151215901
form

solid

form

powder

form

liquid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

storage condition

OK to freeze, protect from light

color

white

color

off-white

color

-

color

white

solubility

water: 50 mg/mL

solubility

DMSO: 100 mg/mL

solubility

-

solubility

DMSO: 50 mg/mL

General description

A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50 = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PARP-1
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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