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324745

Sigma-Aldrich

Elastase Inhibitor III

The Elastase Inhibitor III controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):
Elastase Inhibitor III, HLE Inhibitor, MeOSuc-AAPV-CMK
Empirical Formula (Hill Notation):
C22H35ClN4O7
Molecular Weight:
502.99

Quality Level

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 10 mg/mL
methanol: soluble

shipped in

ambient

storage temp.

−20°C

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Sigma-Aldrich

Sigma-Aldrich

324761

Elastase Inhibitor V

form

solid

form

solid

form

solid

form

lyophilized solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated

color

white

color

off-white

color

white

color

white to off-white

solubility

DMSO: 10 mg/mL, methanol: soluble

solubility

DMSO: 50 mg/mL (Use only fresh DMSO.)

solubility

ethanol: 1 mg/mL, DMSO: 5 mg/mL

solubility

ethanol: 1 mg/mL, water: soluble

General description

A potent inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).
A potent irreversible inhibitor of human leukocyte elastase (HLE)(Ki = 10 µM). Protects against lung injury induced by instillation of elastase.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Human leukocyte elastase (HLE)
Product does not compete with ATP.
Reversible: no
Target Ki: 10 µM against human leukocyte elastase (HLE)

Warning

Toxicity: Standard Handling (A)

Sequence

MeOSuc-Ala-Ala-Pro-Val-CMK

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Fletcher, D.S., et al. 1990. Am. Rev. Respir. Dis.141, 672.
Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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