324888

Sigma-Aldrich

Epigenetic Multiple Ligand - CAS 1020399-52-3 - Calbiochem

A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes.

Synonym(s):
3,5-bis(3,5-Dibromo-4-hydroxybenzylidene)-tetrahydro-2H-pyran-4-one, PRMT Inhibitor IV, Epigenetic Multiple Ligand - CAS 1020399-52-3 - Calbiochem
Empirical Formula (Hill Notation):
C19H12Br4O4
CAS Number:
Molecular Weight:
623.91

storage conditions

+2C to +8C

Quality Level

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light orange

solubility

DMSO: 100 mg/mL

shipped in

ambient

General description

A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes, including H4/PRMT1 (91% inhibition at 50 µM), H4/RmtA (50% inhibition at 29 µM), H3/p300/CBP (61% inhibition at 50 µM), PABP1/CARM1 (>90% inhibition at 100 µM), H3/SET7 (>90% inhibition at 100 µM), SIRT1/2 (>50% inhibition at 25 µM), although the process of Np13p by PRMT1 is only weakly affected. Shown to induce either apoptosis (28% after 30 h incubation with 25 µM inhibitor) or granulocytic differentiation (100% of non-apoptotic cells after 30 h incubation with 5 µM inhibitor) among U937 cell population.
A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes, including H4/PRMT1 (91% inhibition at 50 µM), H4/RmtA (50% inhibition at 29 µM), H3/p300/CBP (61% inhibition at 50 µM), PABP1/CARM1 (>90% inhibition at 100 µM), H3/SET7 (>90% inhibition at 100 µM), SIRT1/2 (>50% inhibition at 25 µM), although the process of Np13p by PRMT1 is only weakly affected. Shown to induce either apoptosis (28% after 30 h incubation with 25 µM inhibitor) or granulocytic differentiation (100% of non-apoptotic cells after 30 hr incubation with 5 µM inhibitor) among U937 cell population.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Mai, A., et al. 2008. J. Med. Chem.51, 2279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin

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