341610

FGF/PDGF/VEGF RTK Inhibitor

The FGF/PDGF/VEGF RTK Inhibitor, also referenced under CAS 144335-37-5, controls the biological activity of FGF/PDGF/VEGF RTK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): FGF/PDGF/VEGF RTK Inhibitor, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII, PDGFR Tyrosine Kinase Inhibitor XVII, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII
• Empirical Formula (Hill Notation): C₁₆H₁₁N₃O₂
• CAS Number: 144335-37-5
• Molecular Weight: 277.28
• MDL number: MFCD00572729
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(nc1c3c(nc4c(c3O)cccc4)O)cccc2
• InChI: 1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
• InChI key: YXCWBNCDJZEBKY-UHFFFAOYSA-N

Description

General description

A cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC₅₀ = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC₅₀ = 420 nM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Renhowe, P.A., et al. 2009. J. Med. Chem.52, 278.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable