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344150

Sigma-Aldrich

FPT Inhibitor I

The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

FPT Inhibitor I

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About This Item

Empirical Formula (Hill Notation):
C19H29NO6P · 3Na
Molecular Weight:
467.38
UNSPSC Code:
12352200

Quality Level

assay

≥85% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: ≥10 mg/mL

shipped in

ambient

storage temp.

−70°C

General description

A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
Potent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Biochem/physiol Actions

Primary Target
Farnesyltransferase (Ftase)
Product does not compete with ATP.
Target IC50: 83 nM against Ftase

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.

Other Notes

Manne, V., et al. 1995. Drug Development Res.34, 121.
Patel, D.V., et al. 1995. J. Med. Chem.38, 2906.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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