A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
Potent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.
Biochem/physiol Actions
Primary Target Farnesyltransferase (Ftase)
Product does not compete with ATP.
Target IC50: 83 nM against Ftase
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
Other Notes
Manne, V., et al. 1995. Drug Development Res.34, 121. Patel, D.V., et al. 1995. J. Med. Chem.38, 2906.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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