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Glial Fibrillary Acidic Protein, Human Brain

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Synonym(s):
GFAP

Assay

≥90% (SDS-PAGE)

Quality Level

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

distilled water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
G9269AG230AB5541
form

lyophilized

form

buffered aqueous solution

form

liquid

form

-

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

solubility

distilled water: 1 mg/mL

solubility

-

solubility

-

solubility

-

shipped in

ambient

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

General description

Native, glial fibrillary acidic protein purified from human brain. Main component of the intermediate filaments in astrocytes. Marker of sclerotic plaques in gliosed brain.
Native, glial fibrillary acidic protein purified from human brain. Marker of sclerotic plaques in brain and gliosed brain. Isolated from normal human brain. A component of astroglial intermediate filaments. Forms glial filaments in astrocytes in the central nervous system and in some Schwann cells in peripheral nerves.



Molecular Weight: 43,000-49,000

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 16 mM Sodium Bicarbonate, pH 8.5.

Preparation Note

Prepared from tissues of individuals that have been shown by certified tests to be negative for HbsAg, HIV-1 and HIV-2 antibodies, HCV, and syphilis.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Anderiva, M., et al. 2001. Glia35, 189.
Masood, K., et al. 1993. J. Neurochem. 61, 160.
Liem, R.K., and Hutchison, S.B. 1982. Biochemistry21, 3221.
Dahl, D. 1973. Brain Res.57, 343.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Ronald J Ellis et al.
Journal of neurology and psychology, 9(1) (2022-01-01)
Astrocytes become activated with certain infections, and this might alter the brain to trigger or worsen depressed mood. Indeed, astrocytes are chronically activated in people with HIV infection (PWH), who are much more frequently depressed than people without HIV (PWoH).
Mohamed B Abou-Donia et al.
Brain sciences, 10(9) (2020-09-10)
For the past 30 years, there has been a lack of objective tools for diagnosing Gulf War Illness (GWI), which is largely characterized by central nervous system (CNS) symptoms emerging from 1991 Gulf War (GW) veterans. In a recent preliminary
John E Buonora et al.
Frontiers in neurology, 6, 68-68 (2015-04-15)
Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include the development of plasma biomarkers for assessing neurologic injury, monitoring pathogenesis, and predicting vulnerability for the development of untoward neurologic outcomes. While several biomarker proteins have
Mohamed B Abou-Donia et al.
Brain sciences, 11(2) (2021-01-28)
Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has
Sharmilee Gnanapavan et al.
PloS one, 8(8), e70019-e70019 (2013-08-13)
Lamotrigine trial in SPMS was a randomised control trial to assess whether partial blockade of sodium channels has a neuroprotective effect. The current study was an additional study to investigate the value of neurofilament (NfH) and other biomarkers in predicting

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