356310

Sigma-Aldrich

Glyburide - CAS 10238-21-8 - Calbiochem

A sulfonylurea that selectively blocks ATP-sensitive K+ channels.

Synonym(s):
Glybenclamide, Glyburide - CAS 10238-21-8 - Calbiochem
Empirical Formula (Hill Notation):
C23H28ClN3O5S
CAS Number:
Molecular Weight:
494.00
MDL number:
Pricing and availability is not currently available.

storage conditions

+15C to +30C

Quality Level

assay

≥98% (TLC)

form

solid

mfr. no.

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 25 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

InChI

1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

InChI key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

General description

A sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide.
Antidiabetic sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. High-affinity binding sites are widely distributed and have been identified in the cardiovascular system, the central nervous system, and pancreatic β-cells. In cultured cells, glyburide enhances insulin action and stimulates the synthesis of glucose transporters. Displays large potency difference in action on pancreatic tissue (IC50 in nM range) and vascular tissue (IC50 in µM range).

Packaging

1 g in Plastic ampoule

Biochem/physiol Actions

Primary Target
ATP-sensitive K+ channels
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Holzmann, S., et al. 1992. Eur. J. Pharmacol.215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther.256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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