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361565

Sigma-Aldrich

GSK3β Inhibitor XIX, IM-12

The GSK3β Inhibitor XIX, IM-12 controls the biological activity of GSK3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonym(s):
GSK3β Inhibitor XIX, IM-12, IM-12
Empirical Formula (Hill Notation):
C22H20FN3O2
Molecular Weight:
377.41

Quality Level

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange-yellow

solubility

DMSO: 100 mg/mL
DMSO: soluble

shipped in

ambient

storage temp.

2-8°C

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GSK3β Inhibitor XIX, IM-12 The GSK3β Inhibitor XIX, IM-12 controls the biological activity of GSK3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

361565

GSK3β Inhibitor XIX, IM-12

GSK-3β Inhibitor XI The GSK-3β Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

361553

GSK-3β Inhibitor XI

GSK-3 Inhibitor XXII, Compound A

361563

GSK-3 Inhibitor XXII, Compound A

GSK-3β Inhibitor XII, TWS119 The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

361554

GSK-3β Inhibitor XII, TWS119

form

powder

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

General description

A cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Schmole, AC., et al. 2010. Bioorg. Med. Chem.18, 6785.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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