370681
OXE-R-G βγ Coupling Modulator, Gue1654 - Calbiochem
Synonym(s):
7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole, N-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
color
tan
solubility
DMSO: 25 mg/mL
General description
A membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, but not preexisting OXE-R-Gαβ interaction. Shown to selectively inhibit OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream signalings in HEK293 as well as primary human eosinophils and neutrophils (Effective Conc. 1 to 30 μM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs, including PGD2 receptor CRTH2 (DP2), IL8 receptors CXCR1/2, muscarinic receptor, and C5a receptor. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
A membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, without affecting preexisting OXE-R-Gαβ interaction. Selectively inhibits OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream cellular signalings (Effective Conc. 1 to 30 μM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
Biochem/physiol Actions
OXE-R-Gβγ coupling
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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