The HDAC Inhibitor XIX, Compound 2, also referenced under CAS 6953-61-3, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
A cell-permeable aryl-hydroxamate compound that selectively inhibits the activity of HDAC8 (IC50 = 14 µM) over class I HDAC1 and class II HDAC6 (IC50 >100 µM) without affecting the overall H4 acetylation level in BE(2)-C cultures even at concentrations as high as 20 µM. HDAC8 downregulation by either Compound 2 (10 to 40 µM) or siRNA in neuroblastoma cultures is reported to result in growth inhibition accompanied by neurite-like morphological changes. Compound 2 effectively enhances tubulin acetylation in both HeLa and HEK 293 cultures, indicating that alternative cellular enzyme(s) other than HDAC6 can be targeted for regulating tubulin acetylation.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Oehme, I., et al. 2009. Expert Opin. Investig. Drugs18, 1605. Oehme, I., et al. 2009. Clin. Cancer Res.15, 91. KrennHrubec, K., et al. 2007. Bioorg. Med. Chem. Lett.17, 2874.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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