3867

Sigma-Aldrich

Hydrocortisone - CAS 50-23-7 - Calbiochem

Steroid hormone of the adrenal cortex with anti-inflammatory properties.

Synonym(s):
Cortisol, Hydrocortisone - CAS 50-23-7 - Calbiochem
Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
Molecular Weight:
362.46
MDL number:

storage conditions

+15C to +30C

Quality Level

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 15 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

General description

Steroid synthesized by the adrenal cortex. Important in the regulation of protein, nucleic acid, and lipid metabolism. Pharmacologically, hydrocortisone is used to suppress the inflammatory response.
Steroid hormone of the adrenal cortex with anti-inflammatory properties.

Packaging

1 g in Glass bottle

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Steroid hormone of the adrenal cortex with anti-inflammatory properties

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Preparation Note

Heating to 37°C may be required for complete solubilization.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

hazcat

Repr. 1A - STOT RE 2

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Abhishek Mukherjee et al.
PLoS computational biology, 16(10), e1008300-e1008300 (2020-10-10)
Large nuclear deformations during migration through confined spaces have been associated with nuclear membrane rupture and DNA damage. However, the stresses associated with nuclear damage remain unclear. Here, using a quasi-static plane strain finite element model, we map evolution of...

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