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390238

Camptothecin

from Camptotheca acuminata, ≥95% (HPLC), powder, DNA topoisomerase I inhibitor, Calbiochem®

Synonym(s):

Camptothecin, 10-Hydroxy-, Camptotheca acuminata, 10-Hydroxycamptothecin, HCPT

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25 MG

$205.00

$205.00

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About This Item

Empirical Formula (Hill Notation):
C20H16N2O5
CAS Number:
64439-81-2
Molecular Weight:
364.35
MDL number:
MFCD00189425
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

Camptothecin, 10-Hydroxy-, Camptotheca acuminata, A cell-permeable powerful DNA topoisomerase I inhibitor.

storage condition

OK to freeze

color

pale yellow

SMILES string

[n]21c(cc5c([c]2=O)COC(=O)C5(O)CC)c3nc4c(cc3C1)cc(cc4)O

InChI

1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3

InChI key

HAWSQZCWOQZXHI-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

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This Item
208925400010499610
Camptothecin, 10-Hydroxy-, Camptotheca acuminata A cell-permeable powerful DNA topoisomerase I inhibitor.

Sigma-Aldrich

390238

Camptothecin, 10-Hydroxy-, Camptotheca acuminata

Camptothecin, Camptotheca acuminata A cell-permeable DNA topoisomerase I inhibitor.

Sigma-Aldrich

208925

Camptothecin, Camptotheca acuminata

Caspase-1 Inhibitor I The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

400010

Caspase-1 Inhibitor I

(5Z)-7-Oxozeaenol, Curvularia sp. (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC50 = 8 nM).

Sigma-Aldrich

499610

(5Z)-7-Oxozeaenol, Curvularia sp.

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA topoisomerase I
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
A cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.

Other Notes

Zhang, X.W., et al. 1999. Anticancer Drugs.10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org.Chem.34, 1364.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H340

Hazard Classifications

Acute Tox. 3 Oral - Muta. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mengfan Tang et al.
Nucleic acids research, 49(13), 7476-7491 (2021-07-02)
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we performed whole-genome CRISPR screens to discover genetic alterations
Venugopal R Bovilla et al.
Biomedicines, 9(9) (2021-09-29)
Nuclear factor erythroid-2 related factor-2 (Nrf2) is an oxidative stress-response transcriptional activator that promotes carcinogenesis through metabolic reprogramming, tumor promoting inflammation, and therapeutic resistance. However, the extension of Nrf2 expression and its involvement in regulation of breast cancer (BC) responses

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